منابع مشابه
NOACs; Friend or Foe?
New oral anticoagulants (NOAC’s) are becoming more popular as antithrombotic agents for the prevention of venous thromboembolism in atrial fibrillation and as prophylaxis in hip and knee surgery. With simple administration, rapid onset, few drug interactions and the absence of coagulation monitoring, NOAC’s appear as a friend in the prevention of thromboembolic events. Undoubtedly patients woul...
متن کاملLack of reversibility for NOACs
Dear Editor, I read with interest the recent discussion on the ENGAGE-AF trial written by Kaba et al. The authors provide a comprehensive discussion of the novel oral anticoagulant (NOAC), Edoxaban. However, it is important to remind the readers that although NOACs are being promoted as first line for stroke prevention in atrial fibrillation, there is considerable risk of bleeding associated wi...
متن کاملResponse to ‘Lack of reversibility for NOACs’
Dear Editor, The points raised by Al-Kindi are well made and we accept concerns raised about the current lack of reliable reversal agents for the NOACs. This is also relevant to surgeons and interventionists, not least when performing percutaneous ablation therapy for atrial fibrillation, which is now routinely undertaken without discontinuing warfarin in those patients who are on this therapy....
متن کاملWell-managed warfarin is superior to NOACs.
Limitations of the NOAC randomized controlled trial (RCT) evidence base The multinational NOAC RCTs demonstrated noninferiority to warfarin at and below the following mean international normalized ratio (INR) time in therapeutic range (TTR): 64% for dabigatran in the RELY (Randomized Evaluation of Long-term Anticoagulation Therapy) trial ; 55% for rivaroxaban in the Rocket-AF (Rivaroxaban Once ...
متن کاملNOACs vs. Warfarin for Stroke Prevention in Nonvalvular Atrial Fibrillation
Atrial fibrillation is a heart arrhythmia associated with increased risk for ischemic stroke. Vitamin K antagonists were developed to decrease a patient's clotting risk; however, these medications require therapeutic monitoring and have several drug interactions. Novel oral anticoagulants (NOACs) were developed as an alternative to vitamin K antagonists and several studies have evaluated the ab...
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ژورنال
عنوان ژورنال: Canadian Medical Association Journal
سال: 2016
ISSN: 0820-3946,1488-2329
DOI: 10.1503/cmaj.1150087